Short Description
The Orbitrap Eclipse Tribrid mass spectrometer (ThermoFisher) includes 3 mass analyzers, i.e. a quadrupole mass filter, a linear ion trap and an Orbitrap mass analyzer and 2 detectors. The instrument allows different and partially complementary fragmentation techniques, which are collision induced dissociation (CID), higher-energy collisional dissociation (HCD), electron transfer dissociation (ETD) and a combination of ETD and HCD called EThcD.
One application of this instrument is multiplex quantitation of TMT-labelled samples as this instrument offers a novel method called MultiNotch MS3 combined with real time search option, which provides a higher accuracy of TMT quantification. Additionally, we use the instrument for the analysis of peptides with labile post-translational modifications such as arginine phosphorylation.
https://www.thermofisher.com/at/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-tribrid-mass-spectrometers/orbitrap-eclipse-tribrid-mass-spectrometer.html
Contact Person
Karl Mechtler
Research Services
Please refer to: https://www.viennabiocenter.org/vbcf/proteomics/
Methods & Expertise for Research Infrastructure
Please refer to: https://www.viennabiocenter.org/vbcf/proteomics/