Short Description
A precise molecular understanding of the heterogeneity of tissues in higher organisms is crucial for answering a number of key biomedical questions. The 10x Xenium Station enables detailed molecular analysis of defined areas within complex, heterogeneous tissue samples at both the protein and mRNA levels in high-plex formats. The technology provides a spatial-molecular picture of complex biological samples by generating whole transcriptomes and profiling data for hundreds of validated protein analytes from selected tissue sections. This enables researchers to study the multiple cellular and molecular interactions between, for example, cancer cells, cells of the microenvironment, and therapeutically relevant cells of the immune system with unprecedented precision. The 10x Xenium Station thus represents a robust and flexible technology platform that greatly accelerates the path from the discovery of biomedically relevant processes to translational research questions.
Contact Person
Prof. Dr. Fritz Aberger
Research Services
Spatially highly resolved mRNA and protein profiles from defined regions of complex human and murine tissue sections
Methods & Expertise for Research Infrastructure
Xenium technology expands the methodology of genomics and proteomics. Xenium technology enables the creation of spatial expression profiles within histological sections of complex human and murine tissues with unprecedented resolution, precision, and depth.
Allocation to research infrastructure
PLUS Focus CTB
University Hospital Salzburg
Paracelsus Medical Private University (PMU)
2024
Jutta Horejs-Höck (Universität Salzburg)
FFG
https://www.plus.ac.at/biowissenschaften/forschung/cellcomm/
spaXio - Spatial Crosstalk in Immuno Oncology
2025
Dirk Schmidt-Arras, Peter Krenn, Jutta Horejs-Höck (Universität Salzburg)
European Union MSCA
https://www.spaxio.eu/
FWF SFB EpiFlaMe
2025
GRATZ, Iris; ABERGER, Fritz; WESSLER, Silja; SCHMIDT-ARRAS, Dirk; FORTELNY, Nikolaus;
FWF
www.plus.ac.at/epiflame
