Kurzbeschreibung
The NovaSeq X Plus enables the scaling of ambitious, ultra-high-throughput projects by delivering up to 16 Tb of output (25 billion reads) through high-density optics and flexible flow cell configurations. Leveraging XLEAP-SBS chemistry, the system ensures peak data accuracy and performance while significantly improving operational stability and sustainability.
Ansprechperson
Klaus Wagner
Research Services
Access via the Institute for Diagnosis and Research in Human Genetics
Methoden & Expertise zur Forschungsinfrastruktur
The NovaSeq X Plus facilitates cost-effective whole-genome sequencing (WGS) with a capacity of up to 128 samples per run, alongside a diverse suite of specialized Next-Generation Sequencing (NGS) applications. By providing high-throughput processing at a reduced cost per library, the platform enables the D&F Center for Molecular BioMedicine to execute large-scale genomic, transcriptomic, and epigenetic profiles including exome, RNA-seq, single-cell RNA-seq, ChIP-seq, ATAC-seq, and methyl-seq with enhanced temporal and fiscal efficiency.
Complementing the hardware infrastructure, the facility integrates optimized bioinformatics pipelines tailored for accelerated and high-fidelity secondary data analysis. This platform ensures high analytical sensitivity and specificity across various omics modalities. Furthermore our bioinformatic infractructure automates the generation of standardized data outputs (including FASTQ, BAM/CRAM, VCF, and .txt formats) to support downstream tertiary analysis.
The NovaSeq X Plus serves as a foundational element of the service infrastructure at the Diagnostic & Research Institute of Human Genetics, operating under official accreditation as a medical laboratory in accordance with EN/ISO 15189 standards. This ensures that all genomic analyses meet the highest international benchmarks for quality management and technical competence in clinical diagnostics.