Kurzbeschreibung
The Mass Spectrometry Facility started as proteomics service within the Life Sciences Facility (now Lab Support Facility) in 2019 and was established as independent Scientific Service Unit (SSU) in 2025. Currently, we are a team of five that supports scientists, mainly from life sciences and chemistry, in all research projects that require mass spectrometric measurements.
For that, our experts operate three state-of-the-art high-performance liquid chromatography-coupled high-resolution mass spectrometers to analyze your samples with a broad spectrum of already implemented methods. Furthermore, we offer scientist training on and access to several GC/MS, LC/MS, and other analytical chromatographic instruments.
Ansprechperson
Martin Zehl
Research Services
The MassSpec Facility supports scientists, mainly from life sciences and chemistry, in all research projects that require mass spectrometric measurements. We can assist you all the way from planning, sample preparation, data acquisition and analysis, interpretation of the results, data deposition, and finally publication of your research.
Methoden & Expertise zur Forschungsinfrastruktur
The MassSpec Facility provides the following routine services:
Chemistry:
1) Acquisition of high-resolution ESI mass spectra of non-volatile, soluble, organic compounds, metal-organic complexes, natural products, and peptides to confirm/determine the accurate molecular weight and verify the sum formula (mass accuracy < ±5 ppm).
2) Acquisition of high-resolution CID spectra to support structure elucidation or peptide sequencing.
3) GC/MS analysis of volatile compounds (low-resolution EI mass spectra).
4) User training for our bookable systems.
5) Support in data processing and analysis.
Life Sciences:
1) Acquisition of high-resolution LC-MS data of intact proteins and charge state deconvolution.
2) Targeted metabolomics (i.e., relative or absolute quantitative measurement of selected metabolites in complex samples).
3) Proteomics (including help with the sample preparation, data acquisition, and basic data analysis):
* Shotgun proteomics (DDA or DIA) of complex samples, such as homogenized total tissues or cell pellets.
* Protein ID from gel bands and pull-downs (e.g., co-immunoprecipitation).
* Phosphoproteomics.
4) User training for our bookable systems.
5) Support in data processing and analysis.