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Core Facility (CF)

Neuroimaging Research Core Facility

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Medizinische Universität Innsbruck

Innsbruck | Website

Open for Collaboration

Kurzbeschreibung

Neuro Imaging Research Core Facility: Hochauflösende und schnelle Bildgebung des zentralen und peripheren Nervensystems. Neben den strukturellen Aufnahmen besteht langjährige Expertise in funktioneller Bildgebung sowie hochauflösende in-vivo MR Spektroskopie (1H und 31P).

Ansprechperson

Univ.-Prof. Dr. Elke Gizewski

Research Services

fMRT, Strukturbildgebung, 31P- und 1H-MRS, quantitative imaging

Methoden & Expertise zur Forschungsinfrastruktur

Hochauflösende und schnelle Bildgebung des zentralen und peripheren Nervensystems. Neben den strukturellen Aufnahmen besteht langjährige Expertise in funktioneller Bildgebung sowie hochauflösende in-vivo MR Spektroskopie (1H und 31P). Zudem haben wir eine Expertise in quantitativer Bildgebung (z.B. R2* und T1-Mapping, QSM). In den letzten Jahren haben wir auch mit Deep Learning unterstützte Analysen etabliert.

Nutzungsbedingungen

https://www.i-med.ac.at/forschung/core-facilities/cf-neuro-imaging.html.de

Referenzpublikationen

Volumetric MRI-based response assessment and prognostic value in newly diagnosed glioblastoma: RANO 2.0 versus mRANO versus RANO.
Heugenhauser J, Orth W, Sarcletti M, Iglseder S, Kerschbaumer J, Freyschlag CF, Nevinny-Stickel M, Grams A, Nowosielski M.
Neurooncol Adv. 2026 Feb 12;8(1):vdag032. doi: 10.1093/noajnl/vdag032. eCollection 2026 Jan-Dec.
PMID: 41835953 Free PMC article.

Deep Learning Framework for Automated MRI Planimetry in Multiple Sclerosis.
Mangesius S, Schiefeneder D, Schwab M, Tiefenthaler M, Deisenhammer F, Haltmeier M, Gizewski ER.
Int J Biomed Imaging. 2026 Mar 6;2026:4456355. doi: 10.1155/ijbi/4456355. eCollection 2026.
PMID: 41799369 Free PMC article.

Genotype and Age at Onset Drive Vermis Atrophy in CACNA1A- and GAA-FGF14-related Ataxias.
Indelicato E, Nachbauer W, Amprosi M, Pellerin D, Mangesius S, Gizewski ER, Kiechl S, Brais B, Boesch S, Krismer F; Alzheimer’s Disease Neuroimaging Initiative.
Cerebellum. 2026 Mar 4;25(2):29. doi: 10.1007/s12311-026-01966-8.
PMID: 41775907 Free PMC article.

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population.
Defrancesco M, Gizewski ER, Steiger R, Virgolini I, Kroiss A, Schurr T, Görtz JP, Marksteiner J, Hofer A, Humpel C.
Front Aging Neurosci. 2026 Feb 13;18:1714247. doi: 10.3389/fnagi.2026.1714247. eCollection 2026.
PMID: 41767841 Free PMC article.

Safety of Physical Activity After Cervical Artery Dissection.
Mayer-Suess L, Kaufmann J, Traenka C, Felicetti S, Kaufmann S, Dejakum B, Enz LS, Ratzinger G, Truessel S, Gizewski ER, Kiechl S, Engelter S, Knoflach M.
Eur J Neurol. 2026 Mar;33(3):e70548. doi: 10.1111/ene.70548.
PMID: 41738685 Free PMC article.

Simple diameters, accurate stages:a practical approach to HD-ISS staging.
Heim B, Krismer F, Hemicker G, Cerejo C, Schwarzova K, Labrecque S, Carbone F, Peball M, Scherfler C, Mahlknecht P, Grams AE, Gizewski ER, Djamshidian A, Seppi K.
J Neurol. 2025 Nov 14;272(12):760. doi: 10.1007/s00415-025-13409-1.
PMID: 41239019 Free PMC article.

Assessing a Stimulator Modification for Simultaneous Noninvasive Auricular Vagus Nerve Stimulation and MRI.
Teckentrup V, Ludwig M, Seibt J, Hartig R, Preissl H, Schuppert M, Avdievich NI, Scheffler K, Priovoulos N, Ehses M, Poser BA, Wiggins CJ, Trautner P, Honerbach W, Jacobs HIL, Speck O, Hämmerer D, Kroemer NB.
J Neuroimaging. 2025 Nov-Dec;35(6):e70098. doi: 10.1111/jon.70098.
PMID: 41199481 Free PMC article. Review.

A Psychological Guide to Upper Face Botulinum Toxin Injections: Baseline Emotional Functions of Facial Expressions.
Hopf AGM, Buchheim A, Hopf M, Cajkovský M, Eilert DW.
J Cosmet Dermatol. 2025 Oct;24(10):e70508. doi: 10.1111/jocd.70508.
PMID: 41118440 Free PMC article. Review.

Response to the letter by Dr. Felix H. Blankenstein regarding "Orthodontic appliances and their diagnostic impact to brain MRI".
Latzko L, Schmit A, Glodny B, Grams AE, Birkl C, Crismani AG.
Clin Oral Investig. 2025 Oct 14;29(11):510. doi: 10.1007/s00784-025-06599-5.
PMID: 41085746 Free PMC article.

Brain Injury and Microstructural Brain Development in Very Preterm Infants with Patent Ductus Arteriosus.
Schreiner C, Sappler M, Höck M, Mangesius S, Michel M, Griesmaier E, Kiechl-Kohlendorfer U, Neubauer V.
Neonatology. 2026;123(1):28-35. doi: 10.1159/000548673. Epub 2025 Oct 4.
PMID: 41045477

Temporal Muscle Thickness Correlates with Functional Decline in Huntington's Disease.
Hemicker G, Cerejo C, Peball M, Schwarzová K, Carbone F, Wimmer B, Krismer F, Mahlknecht P, Djamshidian A, Grams AE, Labrecque S, Seppi K, Heim B.
Mov Disord. 2025 Dec;40(12):2845-2847. doi: 10.1002/mds.70059. Epub 2025 Sep 22.
PMID: 40977449 Free PMC article. No abstract available.

Impact of spontaneous recanalization of occlusive cervical artery dissection on risk of stroke.
Mayer-Suess L, Kaufmann JE, Scherer L, Karisik A, Galijasevic M, Mangesius S, Gizewski ER, Kiechl S, Traenka C, Engelter ST, Knoflach M.
J Neurol. 2025 Sep 11;272(9):627. doi: 10.1007/s00415-025-13371-y.
PMID: 40935924 Free PMC article.

MRI R2* and quantitative susceptibility mapping in brain tissue with extreme iron overload.
Birkl C, Panzer M, Kames C, Birkl-Toeglhofer AM, Rauscher A, Glodny B, Gizewski ER, Zoller H.
Eur Radiol Exp. 2025 Aug 23;9(1):80. doi: 10.1186/s41747-025-00622-w.
PMID: 40848176 Free PMC article.

Mapping the Mind: Gray Matter Signatures of Personality Pathology in Female Adolescent Anorexia Nervosa Persist Through Treatment.
Lenhart L, Gander M, Steiger R, Dabkowska-Mika A, Galijasevic M, Mangesius S, Fuchs M, Sevecke K, Gizewski ER.
J Clin Med. 2025 Aug 1;14(15):5438. doi: 10.3390/jcm14155438.
PMID: 40807058 Free PMC article.

Pituitary function in patients with primary and secondary empty sella.
Steckel L, Gizewski ER, Kaser S.
Front Endocrinol (Lausanne). 2025 Jul 16;16:1632824. doi: 10.3389/fendo.2025.1632824. eCollection 2025.
PMID: 40741178 Free PMC article.

Shape-aware inference scheme for selective extraction of head-neck arteries on computer tomography angiography images.
Tiefenthaler M, Mangesius S, Pereverzyev S Jr, Gizewski ER, Neumann L.
Comput Methods Programs Biomed. 2025 Oct;270:108952. doi: 10.1016/j.cmpb.2025.108952. Epub 2025 Jul 24.
PMID: 40729816 Free article.

Field strength dependence reveals multiple sources of relaxation anisotropy in single and crossing white matter fibers.
Bauer M, Kremser C, Gizewski ER, Lenz C, Birkl C.
Neuroimage. 2025 Sep;318:121394. doi: 10.1016/j.neuroimage.2025.121394. Epub 2025 Jul 24.
PMID: 40714229 Free article.

Arterial wall enhancement indicates higher reperfusion rates in non-ruptured aneurysms after endovascular treatment with stent-assisted coiling.
Ladenhauf V, Galijasevic M, Regodic M, Rass V, Freyschlag C, Deeg J, Gruber L, Swoboda M, Bochnicka J, Mangesius S, Lenhart L, Gizewski ER, Grams AE.
Neuroradiology. 2025 Sep;67(9):2327-2335. doi: 10.1007/s00234-025-03709-8. Epub 2025 Jul 10.
PMID: 40637850 Free PMC article.

Kappa free light chain index predicts long-term disease activity and disability accrual in multiple sclerosis.
Berek K, Schmidauer M, Bsteh G, Auer M, Barket R, Berger T, Di Pauli F, Grams AE, Hassler M, Lenhart L, Milosavljevic D, Zinganell A, Walde J, Deisenhammer F, Hegen H.
Mult Scler. 2025 Sep;31(10):1187-1194. doi: 10.1177/13524585251344807. Epub 2025 Jun 16.
PMID: 40519061 Free PMC article.

Trajectories of Pontine Volume in Patients with Multiple System Atrophy.
Kawabata K, Krismer F, Ito M, Hara K, Bagarinao E, Beliveau V, Péran P, Arribarat G, Traon AP, Meissner WG, Foubert-Samier A, Fabbri M, Gordon MF, Ogura A, Katsuno M, Rascol O, Scherfler C, Seppi K, Watanabe H, Poewe W.
Mov Disord. 2025 Jul;40(7):1369-1378. doi: 10.1002/mds.30182. Epub 2025 Apr 2.
PMID: 40172076 Free PMC article.

Orthodontic appliances and their diagnostic impact to brain MRI.
Latzko L, Schmit A, Glodny B, Grams AE, Birkl C, Crismani AG.
Clin Oral Investig. 2025 Mar 22;29(4):202. doi: 10.1007/s00784-025-06275-8.
PMID: 40119988 Free PMC article.

The Pattern and Stages of Atrophy in Spinocerebellar Ataxia Type 2: Volumetrics from ENIGMA-Ataxia.
Robertson JW, Adanyeguh I, Bender B, Boesch S, Brunetti A, Cocozza S, Coutinho L, Deistung A, Diciotti S, Dogan I, Durr A, Fernandez-Ruiz J, Göricke SL, Grisoli M, Han S, Mariotti C, Marzi C, Mascalchi M, Mochel F, Nachbauer W, Nanetti L, Nigri A, Ono SE, Onyike CU, Prince JL, Reetz K, Romanzetti S, Saccà F, Synofzik M, Teive HAG, Thomopoulos SI, Thompson PM, Timmann D, Ying SH, Harding IH, Hernandez-Castillo CR.
Mov Disord. 2025 Apr;40(4):651-661. doi: 10.1002/mds.30143. Epub 2025 Feb 10.
PMID: 39927598 Free PMC article.

Microstructural Maturation of the Splenium of Corpus Callosum and Cognitive and Motor Outcome in Very Preterm Infants.
Winkler I, Posod A, Gizewski ER, Mangesius S, Neubauer V, Pupp Peglow U, Kiechl-Kohlendorfer U, Griesmaier E.
Neonatology. 2025;122(4):414-425. doi: 10.1159/000543328. Epub 2025 Feb 3.
PMID: 39899995

Dynamic fluctuations in brain iron content during migraine attacks: insights from relaxometry and diffusion tensor imaging.
Birkl C, Filippi V, Steiger R, Frank F, Magnesius S, Gizewski ER, Broessner G.
Front Neurol. 2024 Dec 20;15:1422313. doi: 10.3389/fneur.2024.1422313. eCollection 2024.
PMID: 39758781 Free PMC article.

Cervical Artery Tortuosity Is Associated With Dissection Occurrence and Late Recurrence: A Nested Case-Control Study.
Mayer-Suess L, Knoflach M, Peball T, Mangesius S, Steiger R, Pereverzyev S Jr, Lerchner H, Blache L, Mayr M, Ratzinger G, Kiechl S, Gizewski ER, Pechlaner R.
Stroke. 2025 Feb;56(2):413-419. doi: 10.1161/STROKEAHA.124.049046. Epub 2024 Dec 19.
PMID: 39698737

Temporal atrophy together with verbal encoding impairment is highly predictive for cognitive decline in typical Alzheimer's dementia - a retrospective follow-up study.
Doganyigit B, Defrancesco M, Schurr T, Steiger R, Gizewski ER, Mangesius S, Galijasevic M, Hofer A, Tuovinen N.
Front Psychiatry. 2024 Nov 19;15:1485620. doi: 10.3389/fpsyt.2024.1485620. eCollection 2024.
PMID: 39628497 Free PMC article.

Combined cognitive assessment and automated MRI volumetry improves the diagnostic accuracy of detecting MCI due to Alzheimer's disease.
Defrancesco M, Marksteiner J, Lenhart L, Klingler P, Steiger R, Gizewski ER, Goebel G, Deisenhammer EA, Scherfler C.
Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111157. doi: 10.1016/j.pnpbp.2024.111157. Epub 2024 Sep 29.
PMID: 39349216

Dynamic fluctuations in brain iron content during migraine attacks: insights from relaxometry and diffusion tensor imaging.
Birkl C, Filippi V, Steiger R, Frank F, Magnesius S, Gizewski ER, Broessner G.
Front Neurol. 2024 Dec 20;15:1422313. doi: 10.3389/fneur.2024.1422313. eCollection 2024.
PMID: 39758781

Aneurysmal Wall Enhancement of Non-Ruptured Intracranial Aneurysms after Endovascular Treatment Correlates with Higher Aneurysm Reperfusion Rates, but Only in Large Aneurysms.
Ladenhauf V, Galijasevic M, Regodic M, Helbok R, Rass V, Freyschlag C, Petr O, Deeg J, Gruber L, Mangesius S, Gizewski ER, Grams AE.
Diagnostics (Basel). 2024 Jul 16;14(14):1533. doi: 10.3390/diagnostics14141533.
PMID: 39061670

Could Phosphorous MR Spectroscopy Help Predict the Severity of Vasospasm? A Pilot Study.
Galijasevic M, Steiger R, Treichl SA, Ho WM, Mangesius S, Ladenhauf V, Deeg J, Gruber L, Ouaret M, Regodic M, Lenhart L, Pfausler B, Grams AE, Petr O, Thomé C, Gizewski ER.
Diagnostics (Basel). 2024 Apr 18;14(8):841. doi: 10.3390/diagnostics14080841.
PMID: 38667486

Microstructural Brain Development and Neurodevelopmental Outcome of Very Preterm Infants of Mothers with Gestational Diabetes Mellitus.
Sappler M, Volleritsch N, Hammerl M, Pellkofer Y, Griesmaier E, Gizewski ER, Kaser S, Kiechl-Kohlendorfer U, Neubauer V.
Neonatology. 2023;120(6):768-775. doi: 10.1159/000533335

Peritumoral ADC Values Correlate with the MGMT Methylation Status in Patients with Glioblastoma.
Ladenhauf VK, Galijasevic M, Kerschbaumer J, Freyschlag CF, Nowosielski M, Birkl-Toeglhofer AM, Haybaeck J, Gizewski ER, Mangesius S, Grams AE.
Cancers (Basel). 2023 Feb 22;15(5):1384. doi: 10.3390/cancers15051384

A Multi-Disciplinary Approach to Diagnosis and Treatment of Radionecrosis in Malignant Gliomas and Cerebral Metastases.
Mangesius J, Mangesius S, Demetz M, Uprimny C, Di Santo G, Galijasevic M, Minasch D, Gizewski ER, Ganswindt U, Virgolini I, Thomé C, Freyschlag CF, Kerschbaumer J.
Cancers (Basel). 2022 Dec 19;14(24):6264. doi: 10.3390/cancers14246264.

A deep learning pipeline for the automated segmentation of posterior limb of internal capsule in preterm neonates.
Gruber N, Galijasevic M, Regodic M, Grams AE, Siedentopf C, Steiger R, Hammerl M, Haltmeier M, Gizewski ER, Janjic T.
Artif Intell Med. 2022 Oct;132:102384. doi: 10.1016/j.artmed.2022.102384.

Limbic Responses to Aversive Visual Stimuli during the Acute and Recovery Phase of Takotsubo Syndrome.
Steiger R, Tuovinen N, Adukauskaite A, Senoner T, Spitaler P, Bilgeri V, Dabkowska-Mika A, Siedentopf C, Bauer A, Gizewski ER, Hofer A, Barbieri F, Dichtl W.
J Clin Med. 2022 Aug 20;11(16):4891. doi: 10.3390/jcm11164891

HFP-QSMGAN: QSM from homodyne-filtered phase images.
Beliveau V, Birkl C, Stefani A, Gizewski ER, Scherfler C.
Magn Reson Med. 2022 Sep;88(3):1255-1262. doi: 10.1002/mrm.29260.

Qualitative and Quantitative Comparison of Hippocampal Volumetric Software Applications: Do All Roads Lead to Rome?
Mangesius S, Haider L, Lenhart L, Steiger R, Prados Carrasco F, Scherfler C, Gizewski ER.
Biomedicines. 2022 Feb 12;10(2):432. doi: 10.3390/biomedicines10020432

Attachment status is associated with grey matter recovery in adolescent anorexia nervosa: Findings from a longitudinal study.
Lenhart L, Gander M, Steiger R, Dabkowska-Mika A, Mangesius S, Haid-Stecher N, Fuchs M, Buchheim A, Sevecke K, Gizewski ER.
Eur J Neurosci. 2022 Mar;55(5):1373-1387. doi: 10.1111/ejn.15614

Phosphorous Magnetic Resonance Spectroscopy and Molecular Markers in IDH1 Wild Type Glioblastoma.
Galijašević M, Steiger R, Radović I, Birkl-Toeglhofer AM, Birkl C, Deeg L, Mangesius S, Rietzler A, Regodić M, Stockhammer G, Freyschlag CF, Kerschbaumer J, Haybaeck J, Grams AE, Gizewski ER.
Cancers (Basel). 2021 Jul 16;13(14):3569. doi: 10.3390/cancers13143569.

Characterization and diagnostic potential of diffusion tractography in multiple system atrophy.
Beliveau V, Krismer F, Skalla E, Schocke MM, Gizewski ER, Wenning GK, Poewe W, Seppi K, Scherfler C.
Parkinsonism Relat Disord. 2021 Apr;85:30-36. doi: 10.1016/j.parkreldis.2021.02.027.

Short-term meditation training influences brain energy metabolism: A pilot study on 31 P MR spectroscopy.
Gizewski ER, Steiger R, Waibel M, Pereverzyev S, Sommer PJD, Siedentopf C, Grams AE, Lenhart L, Singewald N.
Brain Behav. 2021 Jan;11(1):e01914. doi: 10.1002/brb3.1914.

Functional connectivity and topology in patients with restless legs syndrome: a case-control resting-state functional magnetic resonance imaging study.
Tuovinen N, Stefani A, Mitterling T, Heidbreder A, Frauscher B, Gizewski ER, Poewe W, Högl B, Scherfler C.
Eur J Neurol. 2021 Feb;28(2):448-458. doi: 10.1111/ene.14577.

Kontakt

Univ.-Prof. Dr. Elke Gizewski
Univ.-Klinik für Radiologie
0043 - 0512 - 504
Elke.Gizewski@i-med.ac.at
https://www.i-med.ac.at
https://www.i-med.ac.at/forschung/core-facilities/cf-neuro-imaging.html.de

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